Rafarma Pharmaceuticals develops new liposome-based medicine for targeted therapy
Rafarma Pharmaceuticals, Inc. (OTC: RAFA) has announced the development of a new drug for colon, pancreas and breast cancer treatment. An extremely promising medicine for the pharmaceutical industry is liposomes carrying a lipophilic prodrug of a widely used antitumor agent merphalan and equipped with tetrasaccharide Sialyl LewisX (SiaLeX).
The use of liposomes as an antitumor agent carrier has been discussed for a long time. It is known that liposomes reduce the toxicity of chemotherapeutic agents due to specific biodistribution between tissues and organs. At the same time, ensuring target delivery has always been challenging because tumor cells are well protected from blood flow drugs by the vascular and interstitial barrier.
Targeted therapy aimed at interacting with specific tumor receptors significantly limits the range of use of such drugs due to the presence of intratumoral heterogeneity: as the tumor progresses, many clones of cells are formed that do not express specific receptors and, therefore, are resistant to therapy.
Cytotoxic vector liposomes preclude this outcome. The carbohydrate ligand SiaLeX can recognize selectins present on the endothelium of tumor-feeding vessels, as well as lectins located on cancer cells. This feature determines the long-term prospects of SiaLeX for the therapy of oncological diseases.
Rafarma Pharmaceuticals sees considerable potential in liposome-based medicine development for targeted therapy. To date, the company has already developed a production scheme and has begun preclinical trials.
ABOUT RAFARMA PHARMACEUTICALS:
Rafarma Pharmaceuticals is a diversified pharmaceutical company dedicated to the new treatments and solutions development for patients in various fields. The business has had a reputation as a reliable manufacturer and distributor since 1930. Rafarma Pharmaceuticals has more than 25 programs in molecular biology, nuclear medicine, immunology, sustainable packaging and many other fields at the moment.
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Source: Rafarma Pharmaceuticals, Inc.